Effect of Etoricoxib on fracture healing - An experimental study
نویسندگان
چکیده
Non-steroidal anti-inflammatory drugs (NSAIDs) including selective cyclo-oxygenase-2 (COX-2) inhibitors are some of the most commonly prescribed medications worldwide. Nonselective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of etoricoxib, a new selective COX-2 inhibitor, on bone healing in rabbits, when given in therapeutic doses. Left femur was osteotomized and fixed with K wire in 36 rabbits. One group was fed etoricoxib (3mg/kg body wt/day) orally, while other group served as control. Radiological, morphological, histological and biomechanical analysis of both groups was done at 4, 8 and 12 weeks. An analysis of various parameters of study showed that etoricoxib, a selective COX-2 inhibitor, has significant inhibitory effect on bone healing at 4, 8 and 12 weeks of follow up. So it was concluded that etoricoxib significantly inhibited bone healing in rabbits especially at earlier phases of fracture healing.
منابع مشابه
Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats
UNLABELLED Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and consequently prostaglandins synthesis. Experimental and clinical evidence has indicated a risk for reparative bone formation r...
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